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When it disappears quickly, skin doesnt always have time to bounce back, especially if collagen and elastin stores are already diminished due to age or lifestyle factors

The mechanisms underlying weight regain are multifactorial and include metabolic adaptation with decreased energy expenditure, hormonal changes affecting appetite regulation, anatomical alterations such as gastric pouch or stoma dilation, and psychosocial factors including maladaptive eating behaviors

Decision matrix Safety considerations researchers should know Both compounds are newer than established GLP-1 agonists , which means their long-term safety profiles are still being characterized

They must ask about concomitant medication use when consulting patients requesting facial fillers and consider recent weight loss with GLP-1 RAs, explaining realistic expectations when combining medication use and dermal fillers

Switching Between Medications If you are not tolerating one medication well, switching to the other is possible but must be managed by a licensed medical provider