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Discussion Main findings In patients with T2DM and a low cardiovascular risk, first-line treatment with SGLT2i and GLP-1RAs led to significant reductions in HbA1c, body weight, and FPG levels

Children under age 18: Semaglutide has not been studied in children so it is unknown whether it is effective and safe in young people

Activation of TGF-1/Smad3 signaling pathway inhibits the development of ovarian follicle in polycystic ovary syndrome by promoting apoptosis of granulosa cells

doi: 10.1016/0196-9781(82)90135-8 150 PerlowMJFreedWJCarmanJSWyattRJ

These drugs help manage insulin resistance, weight, and hormonal imbalances