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Ziyad Al-Aly, MD, FASN, in our Division of General Medicine and Geriatrics, and Chief of the Research and Development Service at the VA Saint Louis Health Care System shared, The revelation about GLP-1 medication is that it really works against all major substances, and it works uniformly, not because it acts against alcohol or opioids or nicotine specifically, but because it is likely acting against the craving itself