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While this might seem counterintuitive since glucagon raises blood glucose, the combined effect with GLP-1 and GIP agonism keeps glucose levels in check while dramatically increasing the metabolic rate

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A phase 3 trial found that high-dose oral semaglutide (50 mg) produced a 12.7% placebo-adjusted weight loss at week 68, comparable to subcutaneous semaglutide in patients without diabetes

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Rihm and colleagues (2019) assessed anticipatory reward responses in a value-based decision-making task

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