glp-1 agonist for prediabetes Holding Agonists Prior to Elective Procedures Comparing Glucagon‐like peptide‐1 receptor agonists

doi: 10.1016/j.neuint.2020.104707 [DOI] [PubMed] [Google Scholar] 12

In head-to-head comparisons of SGLT-2 inhibitors versus GLP-1 receptor agonists, we only observed small differences (hazard ratio 0.92 in the primary analysis), and in several secondary and sensitivity analyses we observed no association

GLP-1 receptors have been identified within myocardial tissue and autonomic centres [21,22,23], with murine studies demonstrating effects on heart rate, endothelial function and regulation of the autonomic nervous system [24,25,26]

In addition, GLP-1R overexpression results in improved cognitive function in mice and GLP-1R knockout severely impairs cognitive ability (5, 117, 118)

Experts say the approval is a positive step toward managing obesity