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3032 Updated guidelines now recommend metabolic-bariatric surgery for patients with body mass index 30 kg/m 2 or greater with metabolic disease, including MASH

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For example, serum levels of the proteoglycan glypican-3 in some patients with hepatocellular carcinoma are elevated through the shedding of glypican-3 from cell surfaces, which interferes with the efficacy of glypican-3-targeted therapy 3