wegovy tirzepatide or semaglutide Zepbound beats for weight loss in first head-to-head trial of blockbuster drugs – Tirzepatide vs. Ozempic: Comparing Diabetes

Dropping pounds too quickly can put you at risk for muscle or bone loss, she adds

Hypoglycemia, though uncommon with tirzepatide monotherapy, can occur in individuals taking concurrent diabetes medications, particularly insulin or sulfonylureas

Avoiding high-fat, greasy, or heavily spiced foods can reduce nausea severity

All patients received a standard lifestyle intervention which included instruction on a reduced-calorie diet (approximately 500 kcal/day deficit) and increased physical activity counseling (recommended minimum of 150 min/week) that began with the first dose of ZEPBOUND, during the lead-in period, and continued throughout the trial

Diet and exercise led to greater gains in QALYs compared with usual care but fewer QALYs compared with semaglutide and tirzepatide