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Learn why patients stop treatment and how clinicians can improve persistence and outcomes.

When cultured human L-cells were deprived overnight of glucose and serum and then exposed to high glucose, 10% FBS, and -carrageenan (1g/ml) for 10minutes, 1h, and 24h, mRNA expression of proglucagon and secretion of GLP-1 were significantly reduced, compared to control cells not exposed to carrageenan

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GLP-1R agonist 2 (compound 2) is an effective GLP-1R agonist that exerts its activating effect by forming hydrogen bonds with the Tyr42, Cys71, and Ser84 residues of GLP-1R

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