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Aside from its weight loss benefits, semaglutide lowers the risk of many chronic diseases linked to obesity, including high blood pressure, heart disease, diabetes, and stroke.

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Specifically, H3K9ac is diminished at oncogenic loci, while acetylation is augmented at tumor suppressor loci, contingent upon the context (Dorna et al., 2025

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However, despite clear evidence that EC cell-derived 5-HT negatively impacts energy balance and glucose homeostasis, the underlying causes of elevated 5-HT levels with obesity and T2D remain unclear