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In addition, although overweight and obesity is markedly more common, some individuals with advanced HF like HFrEF are also cachexic (Rossignol et al., 2015) and may therefore not benefit from the weight-reducing effect of GLP-1 RAs

45 Products that are a combination of a DPP-4 inhibitor and an SGLT2 inhibitor (sitagliptin/ertugliflozin, saxagliptin/dapagliflozin, and linagliptin/empagliflozin) may be used to further lower A1C and provide increased CV benefit in patients who are not meeting A1C goals on dual therapy

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While earlier work focused on direct action on pancreatic beta cells, more recent work has described additional neural actions including a satiety effect

Semaglutide is administered as a convenient, once-weekly injection, which many of our patients at Centra Internal Medicine find preferable to daily oral medications