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Description
Both medications work through distinct pathwayssemaglutide acts on GLP-1 receptors while phentermine is a sympathomimetic amineand overlap in their cardiovascular effects demands careful provider oversight
Many of the classic hormones regulating feeding have a direct impact on the mesolimbic VTA/NAc neurons (Abizaid et al., 2006
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Mechanism of Action Semaglutide exerts its effects through selective agonism of the GLP-1 receptor (GLP-1R), a G-protein coupled receptor (GPCR) expressed in the pancreas, gastrointestinal tract, heart, vasculature, kidneys, and central nervous system
& Langer, H
