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Discontinuation can be as high as 85% by the end of two years of treatment, according to a study conducted by Prime Therapeutics, a pharmacy benefit manager
A meta-analysis of dietary interventions shows high-protein intake (1.21.6 g/kg body weight) and soluble fiber (25 g/day) consistently increase fasting and postprandial GLP-1 levels
The treatment benefit was a reduction in hyperphagia (as measured by a 0-, 5-, or 10-point change on the Hyperphagia Questionnaire for Clinical Trials [HQ-CT])
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This weight loss itself further improves insulin sensitivity and metabolic health
