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Long-Acting Muscarinic Antagonists (LAMAs) The health care providers professional discretion and the patients condition should guide therapy

Neither medication interacts with any food, and they can both be taken with or without food

Monitoring should include assessment of gastrointestinal tolerance, hydration status, renal function, limb measurements, pain levels, mobility, and quality of life indicators

Both represent breakthrough advances in weight management

Phentermine may have a role in specific scenariossuch as short-term use (typically 12 weeks or less) in patients with no cardiac historybut evidence increasingly favors GLP-1 monotherapy as a first-line approach due to better safety margins and sustained weight loss