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Non-peptidic oral GLP-1RAs may eventually reduce supply pressures because they do not require peptide synthesis or cold-chain storage, but this will depend on scalable, cost-efficient manufacturing pathways

Collectively, these studies highlight that, in some species, GLP-1 and LiCl might engage similar central signaling mechanisms and suggest that central GLP-1s anorexigenic effect might be influenced by aversive pathways and gastric discomfort

[DOI] [PubMed] [Google Scholar] 47.Elrick H., Hlad C.J., Jr., Arai Y., Smith A

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A recent comparison of GLP-1RAs versus placebo in both pediatric and adult populations demonstrated the significant efficacy of GLP-1RAs in promoting weight loss, highlighting their potential across diverse age groups (57)