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Additionally, L cells are equipped with GPCRs to detect microbes and their metabolites, and several studies find impacts of GLP-1R and GLP-2R signaling on the gut microbiota composition 31,73,74

Do not use GLP-1s if you: Have a personal or family history of certain types of thyroid cancer (e.g., medullary thyroid carcinoma) or multiple endocrine neoplasia type 2 Have had pancreatitis or gallbladder disease unless cleared by your doctor Are pregnant, planning to become pregnant, or breastfeeding Have severe gastrointestinal disease (consult your healthcare provider) Common side effects may include: Nausea, especially during the first few weeks Constipation or diarrhea Fatigue or low energy Mild stomach cramping Temporary decrease in appetite To reduce side effects, your provider will typically start with a low dose and increase gradually

Lower doses correlate with reduced nausea and diarrhea, a benefit highlighted in Verywell Healths overview of microdosing

This guide covers the side effects after taking the medication - to find out how to safely administer Wegovy, see our helpful guide on How to Take Wegovy Injections