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Description
Weight loss is known to trigger compensatory biology: Increased appetite signaling Reduced resting energy expenditure Heightened food reward sensitivity Stopping GLP-1 therapy at peak dose, without tapering and without reinforcing lifestyle strategies at the exact moment hunger returns, does not allow lifestyle behaviors to take over. Emerging real-world data and obesity physiology suggest a different, more clinically relevant path: Gradual dose reduction rather than abrupt cessation Continued, structured dietary and exercise support Active monitoring during the high-risk post-cessation period We still need randomized trials designed specifically to test tapering and lifestyle-anchored maintenance strategies

Obesity is prevalent within the inflammatory bowel disease (IBD) population

Patients were stratified according to exposure (n=106,454) or non-exposure (n=317,698) to once-weekly semaglutide, and incidence rates and hazard ratios (HR) of NAION were estimated in a multivariable Cox proportional hazard regression model

Understanding Semaglutide and Tirzepatide These aren't "miracle cures," but medications working with your body's natural systems

GLP-1s are no longer the "future" of diabetes care. They're the present now that 23% of first-line diabetes treatment are GLP-1s
