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may escalate to 1 mg or 2 mg weekly based on glycaemic response For oral semaglutide (Rybelsus) used in type 2 diabetes: Starting dose: 3 mg once daily for 30 days Increase to 7 mg once daily

The FDA also looked at postmarket safety data from Japan, where the drug was launched in 2020

Smart Conversation: Ask what pathway the treatment targets, what labs or health factors matter, and how progress will be monitored

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The number that launched it came out of the semaglutide STEP 1 trial, where a body-composition substudy found that close to 40 percent of the weight people lost showed up as lean mass on the scan (Wilding et al., 2021)