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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Kilarkaje N., Yousif M.H., El-Hashim A.Z., Makki B., Akhtar S., Benter I.F

The intricacy and multidimensionality of the mechanisms underlying brain diseases demands such an adequate analytical and generalizing tool allowing taking into account the multifactorial nature of a brain disease, involvement of cross-signaling and interaction between different brain regions and peripheral organs and tissues [85].The principal cause of many brain diseases is insufficient insulin sensitivity (insulin resistance)