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In the periphery, posttranslational processing of preproglucagon in the alpha-cells of the pancreas produces glucagon and a small amount of GLP-1 whereas the main source of peripheral GLP-1 production occurs through the posttranslational processing of preproglucagon in the L-cells of the gut (reviewed in Holst, 2007 and Campbell and Drucker, 1992

A retatrutida um frmaco que se liga a um receptor de trs hormnios que agem no tratamento da obesidade semaglutida e tirzepatida usam, respectivamente, um e dois anlogos de hormnios reduzindo o apetite e aumentando a queima de gordura

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