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In addition, Ex-4 provides neuroprotection against ischemia-induced damage in the hippocampus by downregulating hypoxia-inducible factor-1 and modulating apoptosis through the increased B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X-protein (Bax) ratio, which is mediated by the GLP-1 receptor [48]

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The Study Has Some Limitations The study design comparing people to themselves over time helps reduce some variables among participants that can make findings inconclusive, says Dr

Natriuretic Effect by Exendin-4, But Not the DPP-4 Inhibitor Alogliptin, is Mediated via the GLP-1 Receptor and Preserved in Obese Type 2 Diabetic Mice

5.4 Acute Renal Failure There have been postmarketing reports of worsening renal function, including acute renal failure, sometimes requiring dialysis