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Discussion PCOS is a prevalent, highly heterogeneous condition affecting women of reproductive age, frequently involving metabolic comorbidities

Pancreatic -cells respond to changes in blood glucose levels through insulin secretion, whereas intestinal L-cells respond to various nutrients, such as amino acids, fatty acids, glucose, and bile acids, through incretin secretion under physiological conditions 35

The dose-dependent effect of GLP-1 on decelerating gastric emptying plays a substantial role in improving postprandial glycemic concentrations to the extent that postprandial insulin secretion may no longer be stimulated or could even be reduced (154, 155) ( Figure 1 Section D)