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Description
A recent in vivo study in healthy subjects showed that acute intravenous infusion of GLP-1 during a pancreatic clamp, in which insulin and glucagon levels were maintained at basal levels, caused a reduction in hepatic glucose production, suggesting a potential direct effect on gluconeogenesis [11]

Obesity and weight management for the prevention and treatment of type 2 diabetes: standards of care in diabetes-2024

Participants were required to have a BMI between 28 and 38 kg/m 2 , to have an HbA1c concentration between 6.5 and 9%

Bodnaruc, A

One of the studies, SUSTAIN-6, was a 2-year FDA-mandated cardiovascular-outcomes trial involving 3297 patients
