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Semaglutide vs Tirzepatide for Weight Loss in Adults with Overweight or Obesity

Discontinuation Trends and Persistence Patterns Despite the clinical benefits of GLP-1 receptor agonists, discontinuation remains a challenge

However, the potential of this drug class was turbocharged by the FDAs December 2017 approval of Novo Nordisks weekly injectable Ozempic (semaglutide) and May 2018 approval of Eli Lillys dual agonist Mounjaro (tirzepatide), both for type 2 diabetes

However, if the criteria widened to target age-related diseases, not only will more younger people start taking them but the age range might expand

Under HFHC-fed conditions, livers of Dpp4 / mice but not Dpp4 hep/ mice exhibited upregulation of transcripts associated with the inflammasome and markers of NF-B signaling, pathways characterized to be activated in NAFLD (73, 74)
