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Yet most patients still dont control their blood pressure

GLP-1 has been shown to attenuate meal-induced gastric antral propagated contractions while increasing pyloric tone (159, 160)

Cox proportional hazards models were used to evaluate infection risks, with the proportional hazards assumption tested using the generalized Schoenfeld residuals method

Cardiovascular Safety : The cardiovascular safety of tirzepatide has been evaluated and confirmed to date through a pre-specified meta-analysis of phase 2 and 3 randomized trials comparing tirzepatide with other placebo, insulin glargine, degludec, semaglutide, dulaglutide for a minimum of 26 weeks (including the GPGB, SURPASS 1,2,3,4,5, and J-mono studies) [67]

Close monitoring by the primary care physician is important for effective management of these effects