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Studies have shown that adipose-tissue insufficiency (as in lipoatrophy) induced by adipocyte differentiation disorders leads to high circulating glucose and cholesterol levels, which is a hallmark of and contributor to insulin resistance 49,50

For a broader overview of related reactions, see GLP-1 side effects in 2026

For context on the timeline, tirzepatide weight loss timeline covers what to expect month by month

Patients using semaglutide can, in some cases, achieve a reduction in body weight of around 10-20% over a year, which is substantial compared to other weight loss medications

This guide explains what GLP-1 and GIP actually are, how they differ in function, why combining both creates additive benefits, and what this means for choosing between medications