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Back Fralick, M, Zinman, B (25 Jan 2021) 'The discovery of insulin in Toronto: beginning a 100 year journey of research and clinical achievement', Diebetologia , 64, 947-53

Les essais cliniques en cours sur le rtatrutide dfinissent sa population cible, principalement les adultes souffrant d'obsit ou de surpoids, notamment en prsence de pathologies associes

This suggests the enzyme plays an active role in maintaining obesity, not just responding to it

From a theoretical pharmacological standpoint, combining a peptide with putative lipolytic activity (AOD 9604) with a potent triple incretin receptor agonist (retatrutide) could potentially amplify metabolic effects but this is speculative and raises the possibility of compounding adverse effects with no safety data to guide dosing or monitoring

4 research note