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Some of the largest organizations in the US spend upwards of $16,000 per person per year on costs associated with GLP-1s

Main text Within this review, we provide an overview of the intricate interplay between chronic inflammation of the adipose tissue and the hypothalamus and the development of obesity

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We delineate how systemic metabolic dysfunction, often associated with obesity, synergizes with local inflammation to alter the balance between MMPs and their tissue inhibitors TIMPs, thus contributing to a perpetuating circle of inflammation and fibrosis

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