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Electrophysiological whole-cell voltage- and current-clamp recordings in horizontal or coronal brainstem slices has revealed a rapid leptin-induced depolarization of these NTS GCG + neurons, thus confirming the ability of leptin to directly stimulate central GLP-1 secretion [351]

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doi:10.1001/jama.293.4.455 Zhao K, Shkolnik, B, Lu J, Miller J, Schulsinger D

If you experience any concerns, discontinue use and consult your healthcare provider for personalized guidance