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GLP-1/GIP+B12 Power up your weight loss

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Conclusion Tirzepatide is likely to counteract most of the pathogenetic factors contributing to CKD in T2D, potentially representing a step forward in incretin-based therapy towards nephroprotection

Aims/hypothesis Unimolecular peptides targeting the receptors for glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon (GCG) have been shown to improve glycaemic management in both mice and humans

They work by mimicking a natural gut hormone that helps control blood sugar, slows digestion, and reduces appetite
