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Description
This was recently supported by evidence that AGRP neurons (which when activated potently drive feeding behaviour) project to paraventricular hypothalamic nucleus oxytocin neurons (Figure 2) (Atasoy et al., 2012)

Results inform whether to adjust your current semaglutide dose, add complementary compounds like tirzepatide, or explore oral formulations if injection fatigue develops
The practical result is a formulation that patients are more likely to tolerate at therapeutic doses, more likely to maintain for the full duration of treatment, and more likely to achieve favorable body composition outcomes compared to semaglutide alone

doi: 10.9740/mhc.2016.07.191

Nephron Physiol
