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The upper intake limit for calcium is 2,000-2,500 mg daily (age-dependent), with excessive supplementation potentially associated with cardiovascular and kidney stone risks

10.1002/dmrr.2541 [DOI] [PubMed] [Google Scholar] Zinman B., Bhosekar V., Busch R., Holst I., Ludvik B., Thielke D., et al

Effects of metformin on survival outcomes of pancreatic cancer patients with diabetes: A meta-analysis

Reduced blood flow to your hands and feet can leave them feeling colder than usual