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GLP-1RAs mitigate these adverse impacts by enhancing fatty acid oxidation via the Creb5/NR4a1 signaling axis, thereby reducing mitochondrial damage, lipid accumulation, and ATP deficiency (77, 78, 83)

FDA-approved GLP-1 medications have been shown in clinical studies to support weight management and metabolic health, but they often come with higher out-of-pocket costs, and insurance coverage varies widely

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This review presents an overview of the therapeutic possibilities of six frequently employed DPP4 inhibitors (DPP4is) (Sitagliptin, saxagliptin, vildagliptin, linagliptin, alogliptin and teneligliptin) in managing T2DM, focussing on their characteristics, mechanism of action, advantages and side effects in comparison with alternative oral antidiabetic drugs as well as the possibility of using in silico method in advancing its timely and costeffective production

Prescription is only available after consultation with a licensed provider to determine if treatment is appropriate.