alternative to glp 1 GLP-1 Natural Alternatives: Supporting Metabolic Health Ozempic, GLP-1 Drugs & the

doi: 10.1152/physrev.00034.2006 36 BeiroaDImbernonMGallegoRSenraAHerranzDVillarroyaFet al

Sawami K, Tanaka A, Node K (2022) Anti-obesity therapy for cardiovascular disease prevention: potential expected roles of glucagon-like peptide-1 receptor agonists

Other combinations of entero-pancreatic hormones including cagrisema (GLP-1/amylin RA) and the triple agonist retatrutide (GLP-1/GIP/glucagon RA) have also progressed to phase 3 trials as obesity treatments and early data suggests that may lead to even greater WL than tirzepatide

MASH has replaced the old terminology of NASH (non-alcoholic steatohepatitis) and is defined as the presence of 5 % hepato-steatosis and hepatocyte "ballooning" (inflammation with hepatocyte injury and cell liver death) with or without fibrosis [5,6] [Table 2]

GLP-1 agonist benefits to consider For those who are at greater risk of cardiovascular issues, some of the GLP-1 receptor agonists have shown cardiovascular benefits or a neutral cardiovascular profile