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There is a need for randomized controlled trials to evaluate the efficacy and safety of newer AOMs, such as semaglutide and tirzepatide, within Arab populations to inform culturally and genetically tailored obesity management strategies

It may be that short-acting GLP-1RAs act more like endogenous GLP-1 and communicate to the brain primarily via the vagus nerve, whereas long-acting GLP-1RAs like liraglutide and semaglutide primarily access the brain directly

Frequently Asked Questions Is vomiting a normal side effect of semaglutide, and should I be concerned

Phase 2 trials studied doses of 1 mg, 4 mg, 8 mg, and 12 mg administered once weekly by subcutaneous injection, but it remains unlicensed in the UK

The larger trials look at how well it works