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Secondary findings include a 75.8% reduction in WOMAC pain scores in participants with knee osteoarthritis, a 72% prediabetes-to-normoglycemia reversal rate, and an approximately 20% reduction in LDL cholesterol attributed to glucagon-receptor-driven PCSK9 degradation

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Next, we used CRISPR-Cas9 to mutate two bases in the putative TFAP2 binding motif of the glp-1::v5 promoter ( glp-1prom(aa) ) that are predicted to disrupt TFAP2 binding (Fig

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In 2022, the FDA approved Mounjaro, an injection of the drug tirzepatide, and in 2023, it approved the similar drug Zepbound