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This approach is particularly appropriate for patients with obesity and symptomatic cholelithiasis who would benefit from both interventions

In intestinal L-cells, proglucagon is cleaved by prohormone convertase 1/3 (PC1/3) to generate GLP-1, along with other peptides such as GLP-2, oxyntomodulin, and peptide YY

Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study

That said, some people who struggle with exercise find that GLP-1 therapy creates an indirect exercise benefit

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