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Description
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PF was induced through daily intraperitoneal injections of 0.1% CG in saline at a dose of 10 ml/kg body weight into the peritoneal cavity for 21 consecutive days
Percentage of insulin secreted was determined from the secreted over the total (internal + secreted) insulin concentrations
Subsequent work has demonstrated activity against diet-induced obesity, hepatic steatosis and heart-failure models, positioning SLU-PP-332 as the lead chemical probe for the entire ERR-PGC-1 axis [2,3]
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