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To distinguish between the two subclasses of ionotropic GABA receptor (GABA A and GABA C ), we tested the effects of the specific GABA A and GABA C receptor antagonists, bicuculline methiodide and TPMPA ((1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid), respectively (Chebib, 2004)

Both PKA inhibitors (Rp-cAMP and H-89) and PI3 kinase inhibitors (LY294002 and wortmannin) partially suppressed the anti-apoptotic effect of GLP-1 on MG-induced apoptosis in both INS-1 and MIN6 cells (Fig

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doi: 10.1016/j.ejphar.2012.12.012