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For once-weekly GLP-1 medications, changing the time of day may not materially affect gastrointestinal symptoms

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At these doses, appetite suppression is mild enough to still eat in surplus while limiting "dirty bulk" overeating

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While long-term glycemic control unequivocally reduces the risk of developing and progressing diabetic retinopathy (as demonstrated in the DCCT and UKPDS trials), rapid reduction in blood glucose levels can paradoxically cause temporary worsening of existing retinopathya phenomenon termed "early worsening" or "acute progression." This phenomenon was first documented in the Diabetes Control and Complications Trial (DCCT) and has been observed with intensive insulin therapy and other glucose-lowering interventions