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GLP-1 receptor agonists have become a paradigm shift in treating the two conditions together, and clinical trials have shown an average of 15-22% body weight loss with recent preparations (semaglutide and tirzepatide)

however, some discontinuations were actually due to "perceived excessive weight loss," highlighting the potency of the drug

The DailyMed label for the Retatrutide Pen specifies three recommended injection sites: abdomen, thigh, or upper arm

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