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When compared to single agonists, unimolecular dual incretin was more effective in correcting adiposity-induced insulin resistance in animal models of obesity and diabetes

This underscores the uncertainty surrounding the long-term effects of these agents, which patients may need to take indefinitely to sustain weight loss

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When calories are low, protein becomes even more important because it helps stimulate muscle protein synthesis (MPS), the process responsible for repairing and preserving muscle

However, clinical data shows continuous therapy yields better long-term results than on-and-off cycling