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These compound-specific effects could affect the way in which individual DPP4i are used therapeutically and potentially explain off-target adverse effects, such as hospitalization for heart failure, which is seen only with one DPP4i

doi: 10.1016/j.tem.2020.02.006 133 LudwigDSEbbelingCB

Additional larger prospective studies are needed to further assess the mechanism of action of these drugs on the kidney and, hence, their effect on kidney stones

These agents are believed to suppress presynaptic dopamine release and dampen postsynaptic reward signaling at mesolimbic synapses, thereby diminishing the reinforcing effects of alcohol consumption

Some patients may experience symptoms such as nausea, vomiting, diarrhea, and constipation