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The improved glucose metabolism is mainly due to three closely interacting factors: 1) rapid absorption of glucose from the intestine giving rise to high post-prandial glucose responses, 2) a consequent exaggerated secretion of GLP-1 that act on the -cells, and 3) radically improved hepatic and subsequently peripheral insulin sensitivity [226]

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The hope is that by reducing the dose, you can still lose weight and keep it off without the side effects like nausea, vomiting, and diarrhea

GLP-1 receptor agonists: Beyond their pancreatic effects

And those studies I think what when I look at MCAS and when I look at autoimmune N of one, like maybe N of ten, like I, you know, I think these smaller studies I think provide so much more value because for so many of us, our patients dont align in a large RCT like it just isnt, you know, within there