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This can be a serious side effect

Recently, there have been several MR studies on the association between T2D and SA, such as the study by Shen et al

In fact, SGLT2-i induced osmotic diuresis and reduction in plasma volume potentially activate systemic RAAS, leading to an initial increase of renin levels in the first three-six months of treatment (53)

No established human cycling, combination, or protocol data exist for this compound

doi: 10.1016/j.cmet.2022.08.003
