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Specifically in colon cancer and prostate cancer, exendin-4 increased intracellular cAMP levels while inhibiting glycogen synthase kinase 3 and ERK-MAPK activation, leading to an increase in apoptosis [93]

What if my genetics show I'm a poor GLP-1 responder

And what further troubles insurers is large-scale studies show that GLP-1s dont lead to medical cost savings, at least not in the short term

Patients reported that their daytime voiding frequency decreased from 9.5 times to 7.5 times per day, and nocturia (nighttime urination) resolved in 7 of 19 patients taking dulaglutide compared to only 1 of 16 patients on placebo

That potency is exactly why the dose is not started high: the entire point of a titration protocol is to introduce the compound at a low, well-tolerated level and raise it in slow, roughly four-week steps so the gastrointestinal system can adapt