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Nutrients, 14(15), 3117

Discontinuation of the drug, IV fluid maintenance, and close monitoring led to swift kidney function improvement

Cardiovascular Effects Dose-dependent increases in heart rate were observed with retatrutide: Heart rate increases peaked at approximately 24 weeks Gradually declined thereafter while remaining elevated above baseline This pattern is similar to that observed with other GLP-1 receptor agonists[4] The clinical significance of these heart rate changes requires further evaluation in larger and longer-term studies

GLP-1 receptor agonists may be used in some ulcerative colitis patients, but require individualized assessment