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Description
DPP4 is the enzyme that breaks down GLP-1, so by inhibiting DPP4, GLP-1 may hang around in the system longer

9 The STEP-HFpEF DM randomised controlled trial enrolled 616 patients with obesity (BMI 30 kg/m 2 ) and both HFpEF (LVEF 40%) and T2D

As GLP-1 agonists have garnered attention for management of obesity due to their effect on reducing insulin sensitivity, they are now being considered a therapeutic option for the treatment of PCOS (polycystic ovarian syndrome), one of the most common causes of subfertility, diagnosed via Rotterdams criteria: oligomenorrhea, hyperandrogenism and polycystic ovaries (97)

Aigner, T., Haag, J., Martin, J

Future efforts should address affordability and accessibility through health economic analyses and policy-driven approaches
