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[13] In combination with a reduced calorie diet and increased physical activity, semaglutide (as Wegovy) is indicated to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with established cardiovascular disease and who are either obese or overweight

A large comparative-effectiveness study published in JAMA Internal Medicine analyzed approximately 36,000 patients on SGLT2 inhibitors versus 19,000 on GLP-1 receptor agonists in Denmark (Jensen et al., 2026)

Phase 2 and 3 studies, such as randomized controlled trials, have shown that these agents significantly reduce liver fat content, improve liver enzyme profiles, and promote histological improvements in patients with MASLD and MASH (6, 46)