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A New England Journal of Medicine study directly compared tirzepatide to semaglutide for obesity treatment

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Additionally, patients experiencing severe or persistent gastrointestinal side effectsincluding nausea, vomiting, diarrhea, or abdominal painshould not attempt to self-manage these symptoms, as they may indicate pancreatitis, gallbladder disease (right upper quadrant pain, fever, jaundice), or other serious adverse effects requiring immediate evaluation

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