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It is found that in the clinical follow-up studies of NAFLD patients, compared with the control group, hepatic fat content and ALT levels were not significantly reduced in Lira group and were associated with an increased incidence of gastrointestinal adverse events [118]

Following biological evaluation, molecule 49 (Figure 6) was selected as the hit compound from which compounds 50 and 51 were designed

A reauthorization requirement can also be beneficial

This pilot will be a huge social and healthcare experiment

10.1007/s40259-024-00699-6 [DOI] [PubMed] [Google Scholar] 22.Hamza M, Papamargaritis D, Davies MJ (2025) Tirzepatide for overweight and obesity management